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Vision
11-13-2019, 06:34 PM
https://i.imgur.com/Zt93rc4.jpg
YK11 is a SARM and myostatin inhibitor in one

Japanese researchers are doing tests with a new SARM (https://www.ergogenics.org/sarms.html) , which according to the first publications has a stronger anabolic effect than a classic anabolic steroid such as DHT. YK11 attaches itself to the androgen receptor, produces few androgenic effects and inhibits - in a way that the researchers do not understand - the effect of myostatin (https://www.ergogenics.org/myostatinremmers-archief.html)
You can see YK11 above. If you click on the picture, a larger version will appear. It is a strange molecule that cheerful chemists probably once made while enjoying home-brewed ethanol, and then forgot. The Japanese found him when they screened compounds for androgenic properties. The whole thing is called (17-alpha, 20E) 17.20 - [(1-methoxyethylidene) bis (oxy)] 3-oxo-19-norpregna-4,20-diene 21-carboxylic acid methyl ester .
PubMed only has two studies into YK11. [PubMed: YK11] (https://www.ncbi.nlm.nih.gov/pubmed/?term=yk11) The researchers get their money from a prestigious government fund for young up-and-coming talent. If you get money from such an institution, you are not going to suffice with two publications, but you will be helping a whole mountain of publications into the world. We will hear more about YK11 soon.
In 2011, Yuichiro Kanno of Toho University published a first study on YK11, in which he demonstrated that the brand value connection was a SARM. YK11 attaches itself to the androgen receptor, but initiates in cells only to a limited extent the processes that can lead to the classical side effects of androgens, such as the growth of body hair, the increase of the aggression and growth of the prostate.
Most SARMs have relatively few androgenic side effects, but often - if you compare it with a substance such as testosterone - relatively little anabolic effect. At YK11 that may be different, Yuichiro Kanno reported in 2013 in Biological and Pharmaceutical Bulletin.

In that research, Kanno experimented with C2C12 muscle cells, and not with test animals or humans. Nevertheless, Biological and Pharmaceutical Bulletin found Kanno's article valuable enough to bomb it into a " Highlighted Paper selected by Editor-in-Chief ". That's no wonder. Kanno discovered that muscle cells produce more anabolic factors if you expose them to 500 nanomoles of YK11 than if you expose those same muscle cells to 500 nanomoles of DHT.
https://www.ergogenics.org/2005/yk11sarm2.gif

And take a look. YK11 provides a greater increase in the production of Myf5, MyoD and myogenin than DHT. Myf5, MyoD and myogenin are signal proteins that make muscles grow.
The figure below shows how that is possible. YK11 makes muscle cells produce more follistatin - considerably more than DHT. Follistatin is a strong myostatin inhibitor.


https://www.ergogenics.org/2005/yk11sarm.gif




https://www.ergogenics.org/2005/yk11sarm3.gif


If the researchers switched off the androgen receptor, YK11 lost its anabolic effect. YK11 therefore works via the androgen receptor. If the researchers switched off follistatin, the anabolic effect also disappeared. Proof supplied: YK11 is a SARM and a myostatin inhibitor .
Good old testosterone also stimulates the production of follistatin. [Endocrinology. 2009 Mar; 150 (3): 1259-68.] Maybe with YK11 we have a substance in our hands that is just as good a muscle enhancer as testosterone, but without the side effects.
" YK11 was shown to be an appropriate anabolic SARM, " the researchers write. " However, further investigation is required to elucidate the mechanisms of the differential activation of the follistatin pathway by YK11 and DHT ."

Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways.

Singh R1, Bhasin S, Braga M, Artaza JN, Pervin S, Taylor WE, Krishnan V, Sinha SK, Rajavashisth TB, Jasuja R.
Author information

1Division of Endocrinology and Research Centers in Minority Institutions Core Laboratory, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA. rajansingh@mednet.ucla.edu

Abstract

Androgens are important regulators of body composition and promote myogenic differentiation and inhibit adipogenesis of mesenchymal, multipotent cells. Here, we investigated the mechanisms by which androgens induce myogenic differentiation of mesenchymal multipotent cells. Incubation of mesenchymal multipotent C3H 10T1/2 cells with testosterone and dihydrotestosterone promoted nuclear translocation of androgen receptor (AR)/beta-catenin complex and physical interaction of AR, beta-catenin, and T-cell factor-4 (TCF-4). Inhibition of beta-catenin by small inhibitory RNAs significantly decreased testosterone-induced stimulation of myogenic differentiation. Overexpression of TCF-4, a molecule downstream of beta-catenin in Wnt signaling cascade, in C3H 10T1/2 cells significantly up-regulated expression of myoD and myosin heavy chain II proteins and of follistatin (Fst), which binds and antagonizes native ligands of the TGF-beta/Smad pathway. Gene array analysis of C3H 10T1/2 cells treated with testosterone revealed that testosterone up-regulated the expression of Fst and modified the expression of several signaling molecules involved in the TGF-beta/Smad pathway, including Smad7. Lowering of testosterone levels in mice by orchidectomy led to a significant decrease in Fst and Smad7 expression; conversely, testosterone supplementation in castrated mice up-regulated Fst and Smad7 mRNA expression in androgen-responsive levator ani muscle. Testosterone-induced up-regulation of MyoD and myosin heavy chain II proteins in C3H 10T1/2 cells was abolished in cells simultaneously treated with anti-Fst antibody, suggesting an essential role of Fst during testosterone regulation of myogenic differentiation. In conclusion, our data suggest the involvement of AR, beta-catenin, and TCF-4 pathway during androgen action to activate a number of Wnt target genes, including Fst, and cross communication with the Smad signaling pathway.

PMID: 18948405 PMCID: PMC2654730 DOI: 10.1210/en.2008-0858

Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression.

Kanno Y1, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y.
Author information

1Faculty of Pharmaceutical Sciences, Toho University.

Abstract

The myogenic differentiation of C2C12 myoblast cells is induced by the novel androgen receptor (AR) partial agonist, (17α,20E)-17,20-[(1-methoxyethylidene)bis-(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), as well as by dihydrotestosterone (DHT). YK11 is a selective androgen receptor modulator (SARM), which activates AR without the N/C interaction. In this study, we further investigated the mechanism by which YK11 induces myogenic differentiation of C2C12 cells. The induction of key myogenic regulatory factors (MRFs), such as myogenic differentiation factor (MyoD), myogenic factor 5 (Myf5) and myogenin, was more significant in the presence of YK11 than in the presence of DHT. YK11 treatment of C2C12 cells, but not DHT, induced the expression of follistatin (Fst), and the YK11-mediated myogenic differentiation was reversed by anti-Fst antibody. These results suggest that the induction of Fst is important for the anabolic effect of YK11.

Phill
01-18-2020, 12:11 AM
yk11

Vision
01-18-2020, 03:03 AM
yk11
This is next on my list my dude.. I cant wait!

REHH
01-18-2020, 07:14 AM
yk11

How much YK11 do you run Phil?

Phill
01-18-2020, 07:36 AM
How much YK11 do you run Phil?
10 mg every 6 hours

Vision
01-18-2020, 07:37 AM
10 mg every 6 hours

is that the recommended dosage every 6 hours?

Phill
01-18-2020, 08:08 AM
is that the recommended dosage every 6 hours?
the
recommended dose would be 15 mg per day....but the question is:
recommended by whom? to the doctors maybe?

it's not a drug, it's experimental ... so, let's experiment! ;)

Vision
01-18-2020, 08:39 AM
the
recommended
dose would be 15 mg per day....but the question is:
recommended by whom? to the doctors maybe?

it's not a drug, it's experimental ... so, let's experiment! ;)
Valid point, it's all still research chems at this point no real clinical dosing as of yet for most..

REHH
01-19-2020, 02:12 PM
10 mg every 6 hours

Wow.......40mg a day huh. I was only taking 5 a day.

HFO3
01-19-2020, 02:25 PM
Wow.......40mg a day huh. I was only taking 5 a day.


I expect nothing less from the Phillster :coffee:

@Phill have you used MK677? what dose if so?

Vision
01-19-2020, 03:26 PM
Wow.......40mg a day huh. I was only taking 5 a day.


I expect nothing less from the Phillster :coffee:

@Phill have you used MK677? what dose if so?

What the both of you guys said..
What Philip does no longer surprises me..
If I did anything remotely near the level that he does there's a good chance I wouldn't have any friends or even anybody in my life.. and I would probably put a whole brand new definition on the word antisocial and anxiety..

Phill
01-19-2020, 05:00 PM
I expect nothing less from the Phillster :coffee:

@Phill have you used MK677? what dose if so?
never had the pleasure

REHH
01-22-2020, 05:53 AM
Well I will start back up on the YK11 when I get back from vacation. Gonna go big at 10mg a day...lol

Vision
01-23-2020, 07:04 AM
Well I will start back up on the YK11 when I get back from vacation. Gonna go big at 10mg a day...lol

A lot of people out there that sarms from many different companies often talked about having to increase the dosages or not really feeling the effects until they use a higher amount..
These are the type of products that really display their quality and authenticity with the dosages, much like Cialis or Viagra it's something you simply can't hide and you know instantaneously but then that day.
Would you say that it's fair to make the assessment that these products are authentic and legitimate based on your dosage experience without having to go to high???

A.font401
01-23-2020, 08:36 AM
A lot of people out there that sarms from many different companies often talked about having to increase the dosages or not really feeling the effects until they use a higher amount..
These are the type of products that really display their quality and authenticity with the dosages, much like Cialis or Viagra it's something you simply can't hide and you know instantaneously but then that day.
Would you say that it's fair to make the assessment that these products are authentic and legitimate based on your dosage experience without having to go to high???

In my personal experience with the rad-140 and yk-11 Id honestly see no reason to have to run them at a high dose to see and feel the effects of them. Im not a more is better person, being that I saw great benefits from using the recommended doses.

REHH
01-23-2020, 09:52 AM
A lot of people out there that sarms from many different companies often talked about having to increase the dosages or not really feeling the effects until they use a higher amount..
These are the type of products that really display their quality and authenticity with the dosages, much like Cialis or Viagra it's something you simply can't hide and you know instantaneously but then that day.
Would you say that it's fair to make the assessment that these products are authentic and legitimate based on your dosage experience without having to go to high???

You can see in my log of LGD4033 and MK677 I only ran the recommended dosages listed on the bottles and saw really good results, surprisingly good results at only 8mg LGD4033 and 20mg MK677.

I've only ran the YK11 for a couple weeks on and off so I couldn't make a complete assessment but I did definitely feel the difference when I added the YK at the recommended dosage on the bottle of 5mg a day.

The products seem to be dosed accurately to me because of the good results I observed at the low recommended dosages I was taking