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TU info: a better alternative to cyp for trt
Treatment with the unmodified T molecule is preferred by opinion leaders, with a treatment modality and in a dose which maintains serum T in the physiological range for the full 24 hours of the day. Studies so far show that TU represents an effective, safe, and well tolerated means of androgen treatment in hypogonadal men. At present, clinical experience is available with TU treatment over 9 years (Zitzmann et al 2007). In view of its favorable pharmacokinetic profile TU has been well received. Its advantages over the more conventional injectable T preparations are obvious. The injection frequency is as little as 4 per year. The large fluctuations of plasma testosterone with the conventional T esters are subjectively experienced as unpleasant by many patients. TU, with its more favorable pharmocokinetic profile, did not have these side effects in clinical trials. So the merits of TU are manifest. The traditional testosterone esters developed some 50–60 years ago are relatively cheap. Health economics may delay a wide introduction of TU in the short-term in spite of the obvious advantages over the traditional T esters.
TU treatment is indicated for all forms of hypogonadism. Men with ED and low T may also benefit from TU administration, and the combination of phosphodiesterease 5-inhibitors and TU may be indicated in men who do not respond sufficiently to phosphodiesterease 5-inhibitors alone.
The open questions are related to T therapy in general and apply to other T preparations as well, and relate to prostate cancer. There is no evidence that testosterone causes prostate cancer. But larger, longer-term clinical studies with more patients (comprising 6000 men followed up for 6–8 years) are required to find definitive answers on the interrelationships between T serum levels and the pathophysiology of prostate cancer. However, experts agree that it is responsible clinical practice to treat elderly hypogonadal men with T provided the existing guidelines for monitoring are followed.
Treatment with the unmodified T molecule is preferred by opinion leaders, with a treatment modality and in a dose which maintains serum T in the physiological range for the full 24 hours of the day. Studies so far show that TU represents an effective, safe, and well tolerated means of androgen treatment in hypogonadal men. At present, clinical experience is available with TU treatment over 9 years (Zitzmann et al 2007). In view of its favorable pharmacokinetic profile TU has been well received. Its advantages over the more conventional injectable T preparations are obvious. The injection frequency is as little as 4 per year. The large fluctuations of plasma testosterone with the conventional T esters are subjectively experienced as unpleasant by many patients. TU, with its more favorable pharmocokinetic profile, did not have these side effects in clinical trials. So the merits of TU are manifest. The traditional testosterone esters developed some 50–60 years ago are relatively cheap. Health economics may delay a wide introduction of TU in the short-term in spite of the obvious advantages over the traditional T esters.
TU treatment is indicated for all forms of hypogonadism. Men with ED and low T may also benefit from TU administration, and the combination of phosphodiesterease 5-inhibitors and TU may be indicated in men who do not respond sufficiently to phosphodiesterease 5-inhibitors alone.
The open questions are related to T therapy in general and apply to other T preparations as well, and relate to prostate cancer. There is no evidence that testosterone causes prostate cancer. But larger, longer-term clinical studies with more patients (comprising 6000 men followed up for 6–8 years) are required to find definitive answers on the interrelationships between T serum levels and the pathophysiology of prostate cancer. However, experts agree that it is responsible clinical practice to treat elderly hypogonadal men with T provided the existing guidelines for monitoring are followed.