A little more on how testosterone has some lipolytic potential as me and Austin discussed on yesterday's podcast, and the role of DHEA in fat loss.
As we can see from the linked research, testosterone increases our number of beta-andrenergic receptors (note synergy with clenbuterol, nicotine, growth hormone) and inhibits LDL activity in adipocytes.
I have posted on testosterone's lipolytic capabilities in the past, and how there has been no documented additional fat mass loss in subjects using any more than 300mg/week (even in double that amount).
So we know that testosterone isn't a primarily lipolytic compound by nature, and the lipolytic properties are not linear by nature, but it at least has SOME potential to aid in body fat reduction.
Practical takeaway being, there is no need to run large supra-physiological dosages of testosterone on fat loss phases, there will be no real benefit for the knock on your health markers. Note, this is not representative of all derivatives of testosterone, some AAS such as trenbolone do have additional lipolytic potential via separate mechanisms, although I do recommend staying away from trenbolone on dieting phases where possible. (But that's another post for another day).
Now onto DHEA. I primarily use DHEA in female clients and anecdotally it has been very effective, especially in those that are 30+ whose endogenous levels have dropped off.
'DHEA stimulates resting metabolic rate (RMR) and lipid oxidation, and enhances glucose disposal, by increasing the expression of GLUT-1 and GLUT-4 on fat cell plasma membrane. The insulin-like effect of DHEA would be associated to a decrease of plasma insulin concentrations and, thus, to an increase of the molar ratio between lipolytic hormones and insulin.'.
You guys have seen me harp on about increasing insulin sensitivity for both health and physique purposes, so this is a hormone that has some very useful mechanisms of action alongside it's lipolytic capabilities.
I would recommend a female check their hormonal profile before utilising DHEA, and only use if they have androgen deficiency. DHEA is much more of a forgiving form of androgen replacement for women, given its weak conversion to testosterone. Doses of 25-50mg/day are typical, but again, this must be guided by blood work.
https://www.ncbi.nlm.nih.gov/m/pubmed/10997611/
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As we can see from the linked research, testosterone increases our number of beta-andrenergic receptors (note synergy with clenbuterol, nicotine, growth hormone) and inhibits LDL activity in adipocytes.
I have posted on testosterone's lipolytic capabilities in the past, and how there has been no documented additional fat mass loss in subjects using any more than 300mg/week (even in double that amount).
So we know that testosterone isn't a primarily lipolytic compound by nature, and the lipolytic properties are not linear by nature, but it at least has SOME potential to aid in body fat reduction.
Practical takeaway being, there is no need to run large supra-physiological dosages of testosterone on fat loss phases, there will be no real benefit for the knock on your health markers. Note, this is not representative of all derivatives of testosterone, some AAS such as trenbolone do have additional lipolytic potential via separate mechanisms, although I do recommend staying away from trenbolone on dieting phases where possible. (But that's another post for another day).
Now onto DHEA. I primarily use DHEA in female clients and anecdotally it has been very effective, especially in those that are 30+ whose endogenous levels have dropped off.
'DHEA stimulates resting metabolic rate (RMR) and lipid oxidation, and enhances glucose disposal, by increasing the expression of GLUT-1 and GLUT-4 on fat cell plasma membrane. The insulin-like effect of DHEA would be associated to a decrease of plasma insulin concentrations and, thus, to an increase of the molar ratio between lipolytic hormones and insulin.'.
You guys have seen me harp on about increasing insulin sensitivity for both health and physique purposes, so this is a hormone that has some very useful mechanisms of action alongside it's lipolytic capabilities.
I would recommend a female check their hormonal profile before utilising DHEA, and only use if they have androgen deficiency. DHEA is much more of a forgiving form of androgen replacement for women, given its weak conversion to testosterone. Doses of 25-50mg/day are typical, but again, this must be guided by blood work.
https://www.ncbi.nlm.nih.gov/m/pubmed/10997611/
Sent from my iPhone using Tapatalk