Melatonin - Potent AI?

Check out this research, where melatonin, reservatrol and letrozole were added into breast adipose tissue in vitro.

As we know, aromatisation of testosterone to estrogen can occur at the aromatase enzyme in fat cells.

Both melatonin and reservatrol were found to act as aromatase inhibitors in this co-culture model, however, melatonin was 1000x more potent than reservatrol.

The most surprising finding here was that melatonin was equally as potent as letrozole!

http://www.sciencedirect.com/science/article/pii/S0887233314001040?via=ihub



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So this brings the real question, what does the dose-response curve of melatonin look like with respect to concentration in various tissue types, in vivo.

Interestingly, studies have shown that taking up to 5 milligrams ofmelatonin before sleep or during wakeful hours results in increased blood growth-hormone levels — forming a link between blood melatonin levels and GH release. Melatonin can influence the GH response to endurance and resistance exercise, too.
https://www.ncbi.nlm.nih.gov/pubmed/8370132