That is a masters level explanation of pharmokinetics. Makes me wish I had tried that one before I had to put down the stimulants lol.Longer blood plasma half life. The time to peak free amphetamine levels is about the same as adderall, but since the rate of conversion of the prodrug(lisdexafetamine) to the active(d-amphetamine) slows down as the prodrug concentration decreases, it will give a longer "streaming-in" of amphetamine after the peak.
I prefer it due to it's smoother nature compared to adderall, and I tolerate d-amphetamine better than l-amphetamine(half of adderall is the "l" form, wheras all of vyvanse is in the "d" form. I feel that it works much better when used for the intended purpose, I really even prefer it if abusing it, but oral is the only way to do it. Any other ROA will only increase the time to peak by a matter of an hour or so at best.
That's what my budy wants I don't know why he likes this better
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Longer blood plasma half life. The time to peak free amphetamine levels is about the same as adderall, but since the rate of conversion of the prodrug(lisdexafetamine) to the active(d-amphetamine) slows down as the prodrug concentration decreases, it will give a longer "streaming-in" of amphetamine after the peak.
I prefer it due to it's smoother nature compared to adderall, and I tolerate d-amphetamine better than l-amphetamine(half of adderall is the "l" form, wheras all of vyvanse is in the "d" form. I feel that it works much better when used for the intended purpose, I really even prefer it if abusing it, but oral is the only way to do it. Any other ROA will only increase the time to peak by a matter of an hour or so at best.
That is a masters level explanation of pharmokinetics. Makes me wish I had tried that one before I had to put down the stimulants lol.
But if you are anything like me you wouldn't like it. It was formulated as a "non-abusable" pro drug. The liver can only metabolize a limited amount of lysine at once, so if you do want to get a good effect on it you have to take a lot of it which then lasts in your system for a long time. If you don't like the "rush" and euphoria then I could see it as being a good option though.
The enzyme that does the specific amide bond cleavage between amphetamine and lysine is in your red blood cells. This makes the rate dependent on hematocrit values, as hematocrit goes up, so does the rate. The literature I've read indicates that the exact enzymes are not know, but that they reside in the cytosol of the RBC.
In practice, the "rate-limited" part of that conversion is pretty damn high. Well above the therapeutic dose. As concentration of the drug goes up, so does the rate of conversion. IME, even at 300mg or so, the shit hits damn hard(not as hard as straight amphetamine, of course) and doesn't really seem to last too much longer than taking a single cap. The mechanism seems to make the roller-coaster just as high, but with a bit "shallower" ride up the hill, and not as steep on the way down.
Interesting. Maybe I should give it a go again. Obviously don't want to ask my doctor because I don't want to risk fucking up my current script.. Also, I heard it's really expensive in comparison. Is that right? I currently pay $50 for 90 20mg XRs. Insurance covers about $230. They are also generics btw, brand name costs 100.
And regardless of what anyone says I notice a difference in the generic and the brand name.
my 50mg vyvanse is $270 a month a wanna say without ins? my ins covers all but my copay and I have a savings card for my copay- so zero bucks
its wild to me it last till 5pm for you
at what dose? it does make a slight difference because the dose isn't completely linear- little heavier in the front but it winds up with higher dosing at the rear which could theoretically make the effect seem higher at the end-I suspect I'm on a dose that.s a hair too low
it falls on its face from me if I take it at 730am at 3 on the nose
making sure its ingested with protein and possible l-tyrosine definitely maximizes its dose- the protein stimulates trypsin which is required to cleave the vyvanse
I usually try to knock mine back with protein or at the least a hydrolyzed collagen supp I have
I was super sensitive to peak and decline initially but now I barely notice it
my insurance wont actually pay for generic concerta- true story
they would rather pay for brand
two were pulled off the market last yr- a new one came out
our particular ins isn't known for its generosity so I suspect the data looks pretty terrible for some generics
the protein stimulates trypsin which is required to cleave the vyvanse
(Please read in best Dr. Evil voice)I'll buy your vyvanse if you can deliver it today- my dr is a douche- I ran out yesterday and that's after I skipped a few days because I knew I would run out
I had a final due and was seriously freaking the fuck out
I would never sell my vanse or adderall. Fuckthat. Not getting popped for that or leaving myself short for a few bucks. I get the 70 mg vanse and 60 of the adderall ir, don't need the xr anymore. Honestly i havent been taking the vanse because that shit is seriously strong. I was taking 120 mg a day and fucked myself up a bit. Now Im saving my vanse for emergency and taking 1 30 mg ir a day. Trying to get off that shit for good. It's garbage.
Im an addict.
It is hard. I've done it before with a combination of meth, adderall, and ethylphenidate. It was a real bitch given the pretty complete combined serotonergic/dopaminergic/adrenergic effects of that cocktail. The best method, in my experience, is to just straight-up cold turkey that shit. It will be worse for a shorter period of time. The worst part for me wasn't the emotional/mental aspect, but was the rebound congestion/tiredness response. Just treat the withdraws symptomatically. Add in a little caffeine, an OTC decongestant for daytime, an antihistamine to help with sleep, and an albuterol inhaler. That's about all you can do for the first couple of weeks it will feel like you have a nice head cold, but by the end of the second week, you should start feeling much better. If you can tough it out, 2-4 weeks and you should start feeling much better. Part of the key to a quick recovery is not to take any cheat doses in the first month or you will be pretty much starting from scratch with alot of the withdraw effects. And force yourself to eat, you won't want to, just make yourself do it.
Again, IME, getting off the addiction cycle of amphetamines is much easier than opioids/benzos(I have forced myself off of addictions of both at one time or another), but still in no way fun. I found another key to preventing relapse with stims is not to drink. Every time I had a relapse back on amphetamine/meth it was when I was drinking that I thought It would be a great idea. Then, BAM, back on another week long bender followed by two to three weeks before I felt normal again.
I feel like Im the only non junk here
know what I feel on vyvanse? like I can read a paragraph... know what I feel when it wears off? like I can't
buncha junks
know what I feel on vyvanse? like I can read a paragraph... know what I feel when it wears off? like I can't
Bunch of junks up in here...... I don't fuck with amps, that's just stupid. Does anyone know where to get some good benzos?...lol
Does anybody have this for sale
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