When to get blood drawn to gauge adex efficiency?

ironborn · Feb 23, 2015

I'll be taking 1mg of adex EOD.

How long after I start taking it should I get blood drawn? 1 week? 2 weeks? etc.

Also, when after my dose should I get it drawn? 24 after dose? 2 hours after dose? etc.

Thanks!

Skip Foursome · Feb 23, 2015

I do not have an answer for this, but a damn good question.

Subbed.

ironborn · Feb 23, 2015

Skip Foursome said:
I do not have an answer for this, but a damn good question.

Subbed.

Thanks.

I'm surprised there isn't a sticky for adex and asin like the test e/c testing protocol.

I hope someone can chime in as I'd like to get accurate test results for myself and to share with the board.

ordawg1 · Feb 23, 2015

I know of no protocol for this. I have seen results from one person to the next vary in extremes.Some do real well on adex and not at all on asin etc. Great topic-OD

chocolatemalt · Feb 23, 2015

I don't have the answer but this study seems to show that ED dosing will lead to steady state blood levels by one week. I assume its effect on E2 will work in tandem, i.e. no further delay, but that could be wrong.

http://clincancerres.aacrjournals.org/content/9/1/468s.full

exerciseordie · Feb 23, 2015

ordawg1 said:
I know of no protocol for this. I have seen results from one person to the next vary in extremes.Some do real well on adex and not at all on asin etc. Great topic-OD

This is the guy to listen to! Ordawg is about the best person you can ask these types of questions to.

JMB1911 · Feb 23, 2015

Skip Foursome said:
I do not have an answer for this, but a damn good question.

Subbed.

add me to that list

heavyiron · Feb 23, 2015

If you are on steroids there is no protocol.

JMB1911 · Feb 23, 2015

heavyiron said:
If you are on steroids there is no protocol.

Those are illegal.

Canebrake · Feb 24, 2015

Can I ask what your current cycle is? Why are you needing to run such a high dose?

I crashed myself once and I know that 2 weeks without a dose of Adex brought my levels just above normal.

ironborn · Feb 24, 2015

chocolatemalt said:
I don't have the answer but this study seems to show that ED dosing will lead to steady state blood levels by one week. I assume its effect on E2 will work in tandem, i.e. no further delay, but that could be wrong.

http://clincancerres.aacrjournals.org/content/9/1/468s.full

That's a good read. Thanks for the link.

heavyiron said:
If you are on steroids there is no protocol.

Haha so I guess just get bloods drawn whenever and hope for the best?

BOBCAT said:
Can I ask what your current cycle is? Why are you needing to run such a high dose?

I crashed myself once and I know that 2 weeks without a dose of Adex brought my levels just above normal.

Well the only thing I'm taking that aromatizes is test e and I'm currently taking 400mg/wk. I was on 200mg/wk about 2-3 weeks ago and ran 32.5mg aromasin ED and my E2 levels were constantly 30-32.

I'm hoping that 1mg EOD will be sufficient with double the test at 400mg/week.

Canebrake · Feb 24, 2015

Adex is strong as shit. I won't consider running 1 mg EOD. If I were you start at .5mg EOD. If your joints start to hurt lower the dose. Then get bloodwork done in about 4-6 weeks and see where you are.

ironborn · Feb 24, 2015

BOBCAT said:
Adex is strong as shit. I won't consider running 1 mg EOD. If I were you start at .5mg EOD. If your joints start to hurt lower the dose. Then get bloodwork done in about 4-6 weeks and see where you are.

Thanks. I will consider that. Why do you suggest I wait 4-6 weeks?

chocolatemalt · Feb 24, 2015

ironborn said:
Well the only thing I'm taking that aromatizes is test e and I'm currently taking 400mg/wk. I was on 200mg/wk about 2-3 weeks ago and ran 32.5mg aromasin ED and my E2 levels were constantly 30-32.

I'm hoping that 1mg EOD will be sufficient with double the test at 400mg/week.

My feeling is that once your AI blood levels stabilize after a week, it won't matter when you get bloods drawn. On an EOD schedule I doubt the levels bounce around to any huge degree.

The study I linked shows that 1-wk leveling effect, for one data point, and there's another study (somewhere

) that shows that knocking out all of your aromatase with a strong exemestane dose will result in E2 levels coming back to normal in about five days. I.e. your body will regenerate its aromatase in about that time frame. So, on a rough estimate, the best your body can do is a 20% regen in a day. Continued AI dosing will gum up that new aromatase as well.

ironborn · Feb 24, 2015

chocolatemalt said:
My feeling is that once your AI blood levels stabilize after a week, it won't matter when you get bloods drawn. On an EOD schedule I doubt the levels bounce around to any huge degree.

The study I linked shows that 1-wk leveling effect, for one data point, and there's another study (somewhere ) that shows that knocking out all of your aromatase with a strong exemestane dose will result in E2 levels coming back to normal in about five days. I.e. your body will regenerate its aromatase in about that time frame. So, on a rough estimate, the best your body can do is a 20% regen in a day. Continued AI dosing will gum up that new aromatase as well.

That's a really good way to put it. Thanks!

When to get blood drawn to gauge adex efficiency?

ironborn

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