The studies are what you should be basing it off of. But the 16 week study your referring to was done well. Ill try to pull up more articles but from what incsn gather a day or two off a week will fend off desensitization. The boom dose im referring to is hex solo at 250-500mcgs in one dose. Im sure you have seen the numbers that hex can hit in clinical research so those doses minus the Mod should still exceed that. I really need to get serums to see if the results reflect this. Unfortunately pep companies can be hit or miss. I wish IMR would carry it so there is no apprehension about quality of product.