You should be fine. Here's some light reading I found, lol.
2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
Clinical data
Trade namesRyzolt, Tramal, Ultram
AHFS/Drugs.commonograph
MedlinePlusa695011
Licence dataUS FDA:link
Pregnancy cat.
AU: C
US: C
Legal status
AU: Prescription Only (S4)
CA: ℞-only
UK: POM
US: Schedule IV
Dependence
liability
Low
RoutesOral, IV, IM, rectal
Pharmacokinetic data
Bioavailability70-75% (oral), 77% (rectal), 100% (IM)[1]
Protein binding20%[2]
MetabolismLiver-mediated demethylation and glucuronidation via CYP2D6 & CYP3A4[1][2]
Half-life6.3 ± 1.4 hr[2]
ExcretionUrine (95%)[3]
Identifiers
CAS number27203-92-5
ATC codeN02AX02
PubChemCID 33741
DrugBankDB00193
ChemSpider31105
UNII39J1LGJ30J
KEGGD08623
ChEBICHEBI:9648
ChEMBLCHEMBL1066
Chemical data
FormulaC16H25NO2
Mol. mass263.4 g/mol
SMILES
CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O
InChI
InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1
Key:TVYLLZQTGLZFBW-ZBFHGGJFSA-N
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Tramadol (marketed as the hydrochloride salt by Janssen Pharmaceutica as Ultram, and as generics) is used to treat moderate to moderately severe pain. It has two different mechanisms. First, it binds to the μ-opioid receptor. Second, it inhibits the reuptake of serotonin and norepinephrine.[4]
Tramadol is a centrally acting atypical opioid analgesic with additional serotonin-norepinephrine reuptake-inhibiting effects.[5] It is marketed as a racemic mixture of both R- and S-stereoisomers.[1] This is because the two isomers complement each other's analgesic activity.[1] It is often combined with paracetamol as this is known to improve the efficacy of tramadol in relieving pain.[1] Tramadol is an atypical opioid because it is a serotonin-norepinephrine reuptake inhibitor of and, by itself, a fairly weak μ-opioid receptor agonist.[6][7] Tramadol is metabolised to O-desmethyltramadol, which is a significantly more potent opioid with additional norepinephrine reuptake-inhibiting properties,[1] making it analogous to tapentadol.[8] When taken as an immediate-release oral formulation, the onset of pain relief usually occurs within about an hour.[9]
It was launched and marketed as Tramal by the German pharmaceutical company Grünenthal GmbH in 1977 in West Germany, even though it would take another 20 years for it to be launched in English-speaking countries such as the UK, U.S., and Australia.[5]
Medical uses
Adverse effects
Chemistry
Mechanism of action
Pharmacokinetics
Society and culture
Veterinary medicine
Pin cushion tree
See also
References
External links
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