been on trt for three years. You need to have a clear goal as to what you want to achieve. Initial bloodwork essential. I had really low T. Creams were useless except to increase dihydrotestosterone. Injections of 120-160mg/wk of testosterone cypionate did the trick--but I got estrogen elevations too. After a bunch of tinkering around settled in at 160/wk test, 1/4 mg arimidex eod. I also use hcg to keep the boys from shutting down, and to encourage what natural T production I have. Need to check your numbers at least every three months initially to see how your body is personally adapting. As for safety--I couldn't imagine going back to no trt. I have no bad side effects. I have increased libido, stamina, and ability to build strength. Feel great cardio-wise.