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IGF-3 is a relatively new discovery. Studies are still being conducted. This is the synopsis of the new study by the NCBL, which I can post or elaborate on for you.
[h=1]Insulin-like growth factor-3 (IGF-3) in male and female gonads of the tilapia: development and regulation of gene expression by growth hormone (GH) and 17alpha-ethinylestradiol (EE2).[/h]
What is the difference between LONG R-3 IGF-1 and the standard IGF-1?
"Just as it was mentioned earlier, Long R3 IGF-1 is a chemically altered version of IGF-1. It has added amino acid chains that prevent it from being deactivated by IGF-1 binding proteins in the bloodstream. This gives Long R3 IGF-1 a much longer half-life. It's the 83 amino acid equivalent of IGF-1 that consists of the complete human IGF-1 sequence substituting the Glu (E) to the Arg(R) at position three. The structure also has an added 13 amino acid extension peptide by the N terminus. Overall it's a more biologically active version of the original IGF-1."
How does its effects compare to that of Growth Hormone?
"Long R3 IGF-1 can directly stimulate muscle growth when compared to growth hormone (GH). This is because GH indirectly results in growth and repair by first inducing IGF-1 release in the liver.If you don't have to worry about IGF-1 release in the liver (because your directly injecting the IGF-1), new growth will be optimized."
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