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E-Control Rx 2.0™ can be used with all of our pro-hormones to reduce any possible water retention, eliminate the chance of the development of male breast tissue, and increase sex drive. E-Control Rx 2.0™ should also be taken after using our products as PCT (post cycle therapy) to bring hormone function back to normal once your cycle is completed.
E-Control Rx 2.0™ contains Arimistane, also known as androsta-3,5-deine-7, 17 dione. Arimistane is a potent aromatase inhibitor to decrease circulating levels of estrogen in the body. Simply put, Arimistane will inhibit or reduce the amount of androgens in the body that can convert into estrogen. Arimistane is a suicide aromatase inhibitor, meaning that it binds to the aromatase enzyme, and can not be reversed.
Estrogen is a hormone that is made up of three different compounds, which are estrone, estradiol, and estriol. Estrogen is not only important for human development, but it contributes to the development of secondary sex characteristics. It determines the main characteristics of a man and a woman. Although, estrogen is important in human development, excess estrogen can lead to health risks including breast cancer, weight gain, headaches, and gynecomastia. Having too much or an imbalance of estrogen can negatively impact your performance in the gym. In order to maximize optimal environment for muscle growth and recovery, you want to maximize your body’s testosterone and luteinizing hormones (LH).
So how does Arimistane help with all this?
Arimistane has been developed as a natural metabolite of DHEA known as androsta-3,5-deine-7, 17 dione. Arimistane is a potent aromatase inhibitor to decrease circulating levels of estrogen in the body. Simply put, Arimistane will inhibit or reduce the amount of androgens in the body that can convert into estrogen. Arimistane is a suicide aromatase inhibitor, meaning that it binds to the aromatase enzyme, and can not be reversed. Past in vitro studies show that Arimistane compared to other aromatase inhibitors has a great binding affinity to the aromatase enzyme, which leads to greater effectiveness in shutting down the active of the aromatase enzyme. The binding affinity is measured in Ki value, which measures the how well the aromastase inhibitor binds to the aromatase enzyme. See graph below.
In measuring the effectiveness of the binding affinity to the enzymes, lower Ki value represents higher binding affinity.
Ki value of Arimistane is .22 micromolar (.mu.M)
Ki value of 3-OHAT (3-beta-hydroxyandrost-4-ene-6,17-dione) is 6.5 .mu.M
Ki value of AT (androst-4-ene-3,6,17-trione) commonly referred to as 6oxo is .43 .mu.M
Ki value of formestane (4-hydroxyandrost-4-ene-3,17-dione, 4-OHA, 16) is .6 .mu.M
- Aromatase enzyme increases → estrogen
- Arimastane decreases ↓estrogen
- High estrogen in men will lower ↓LH (luteinizing hormones) in turn lower ↓testosterone
Conclusion: Arimastane = increased ↑LH and increase ↑testosterone