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Bigmurph
09-22-2021, 06:04 AM
RAD140

History:
RAD140 was first described in 2010 by Miller et al. It was developed by Radius Health, an American biotechnologies firm. The drug has since been subject to limited number of in-vitro (cell incubation) and in-vivo studies in animals, where it demonstrated strong anabolic/androgenic separation consistent with drugs of the SARM class. It is presently in the preclinical development stage at Radius for the treatment of breast cancer. Phase I clinical trials were also reportedly planned for patients suffering from severe weight loss associated with cancer. RAD140 is on the WADA banned substance list, and is detectable in doping controls.

Structural Characteristics:
RAD140 is an oxadiazole aniline derived SARM. It has the chemical name 2-chloro-4-((18,25)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2hydroxypropylamino)-3-methylbenzonitrile. It displays high oral bioavailability (65-75% est), and has a half-life that is amenable to once daily dosing

Side Effects:
Anecdotal reports suggest the drug is generally well tolerated with few common reports of side effects. Similar to oral androgens, this drug is expected to negatively impact HDL (good) cholesterol levels and the HDL/LDL ratio. This may increase cardiovascular disease risk.

RAD140 dosage is 10-20mg ed for men and 5-10mg for women. This is another SARM that came from in-vitro studies and they found that it actually has a much higher binding effect for the androgen receptor than testosterone actually did RAD140 also doesn't interact with other steroidal receptors except minimal interaction with progesterone.
This all suggests that RAD140 has a refined anabolic profile.
RAD140 also is shown to be neuroprotective.
RAD140 even has some therapeutic benefits with Alzheimers disease and other neurodegenerative conditions. Note that most androgens have this same effect.
RAD140 is seen as low toxicity as a compound. Meaning liver toxicity is low considering it is compared to other "oral androgens".

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Bigmurph
09-25-2021, 04:50 AM
Roidshop carries all SARMs and peptides

maxmuscle1
11-21-2021, 10:36 AM
UPDATE :

A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140 for breast cancer August 8, 2021 . Radius Health, Inc funding at 6 cities Hospitals in the US.

1
Yale Cancer Center, New Haven, CT
2
Sarah Cannon Research Institute/Tennessee Oncology Nashville, Nashville, TN
3
Washington University School of Medicine, St. Louis, MO
4
Massachusetts General Hospital, Boston, MA
5
Radius Health Inc, Boston, MA
6
Barbara Ann Karmanos Cancer Center, Detroit, MI

Max

Bigmurph
11-22-2021, 05:43 AM
UPDATE :

A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140 for breast cancer August 8, 2021 . Radius Health, Inc funding at 6 cities Hospitals in the US.

1
Yale Cancer Center, New Haven, CT
2
Sarah Cannon Research Institute/Tennessee Oncology Nashville, Nashville, TN
3
Washington University School of Medicine, St. Louis, MO
4
Massachusetts General Hospital, Boston, MA
5
Radius Health Inc, Boston, MA
6
Barbara Ann Karmanos Cancer Center, Detroit, MI

Max

Interesting stuff I know that alot of these peptides and SARMs will eventually hit the mainstream market place